Liver is an important organ of the body which has high rate of metabolism. The oxidative stress or damage caused by free radicals can induce liver damage. Kalonji ( Black Seed, Nigella Sativa) helps in preventing the production of free radicals and enhances antioxidant defense system which reduces the adverse effect on liver. With its free radical scavenger properties and enhancement of antioxidant defense in body, various medical studies have proven the effect of Kalonji in preventing and protecting liver damage. The antioxidant and anti-inflammatory properties of Kalonji makes it the best tonic for liver.